Klinisk prövning på Coronary Arteriosclerosis: Blood samples
Renata Mazzei - Google Scholar
2021-01-04 Most of the effects of statins can be explained by pleiotropic effects independent of their lowering of serum cholesterol; in some cases, these effects have been shown to be a result of the role However, the lipid-lowering effect is not the only effect of action described by researchers that PCSK-9 inhibitors have. This paper is a review of the literature describing the pleiotropic effects of PCSK-9 inhibitors, which belong to a group of drugs that are being increasingly used, especially when standard lipid-lowering therapy fails. MECHANISM OF ACTION, AND PLEIOTROPIC EFFECTS Sylvia Christakos, Puneet Dhawan, Annemieke Verstuyf, Lieve Verlinden, and Geert Carmeliet Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey; and Laboratory of Clinical and Experimental Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene.
A pharmaceutical company called Pharnext has developed a treatment for a rare, incurable neurodegenerative condition called Charcot-Marie-Tooth disease, which is caused by a single-gene duplication. pleiotropy. the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Definition of pleiotropic. : producing more than one effect especially : having multiple phenotypic expressions a pleiotropic gene. An antagonistically pleiotropic gene can be selected for if it has beneficial effects in early life while having its negative effects in later life because genes tend to have larger impacts on fitness in an organism's prime than in their old age.
It is thought that the studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants It is ubiquitously expressed and exerts pleiotropic effects in various contexts. We have recently generated a Shb knockout mouse and note abnormalities in Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi.
1999;149(8-10):217-24. Siegel, G, et al., Inhibition of arteriosclerotic plaque development by 1909 Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals - Reissmann, Ludwig, 2013 Rabbits – their domestication Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Statins have pleiotropic effects-that is, they are simultaneously capable of producing more than one benefit, and in cardiovascular risk reduction, they accomplish more than simply lowering cholesterol.
pleiotropic - Swedish translation – Linguee
PLoS Genet. 29 nov. 2013 — In the simplest terms pleiotropy means genetic side-effects: a pleiotropic gene is a gene that does several things and a pleiotropic variant is a Testosterone causes pleiotropic effects on cleanerfish behaviour. MC Soares, R Mazzei, SC Cardoso, C Ramos, R Bshary. Scientific reports 9 (1), 1-10, 2019. Research has indicated that statins also possess some pleiotropic effects that are independent of the cholesterol lowering properties.
This finding of differential pleiotropy suggests that peptide motifs
Pleiotropy refers to the phenomenon by which a gene pair at a single locus affects many (more than one) phenotype characteristics. For instance, in albino. Today we are going to be discussing how different traits can be expressed, and the way in which a trait is expressed can have an effect on a person's genotype or
Oct 17, 2008 Statin administration has been associated with the depletion of peripheral blood monocytes, which play a pivotal role in immune response. Pleiotropic gene has a multiple phenotypic effect because it can control expression of a number of characters. Example, Sickle cell anemia, cystic fibrosis ,
Jul 8, 2020 The gene having a multiple phenotypic effect because of its ability to control expression of two or more characters is called pleiotropic gene. The multiple phenotypic effect of a single gene is called pleiotropism.
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Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene The pleiotropic effects attributed to statins are many. 1,2 They include increases in endothelial nitric oxide formation; flow-mediated vascular dilatation; suppression of vascular inflammation; reduction of circulating biomarkers that indicate inflammation (such as C-reactive protein); a reduction in T-cell activation with a decrease in cytokines; promotion of neovascularization in ischemic tissue; and modulation of thrombosis and coagulation. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects.
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Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
It is thought that the studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants It is ubiquitously expressed and exerts pleiotropic effects in various contexts. We have recently generated a Shb knockout mouse and note abnormalities in Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi. Journal of Bacteriology, Vol. 186, (7) : 2074-2084. Östberg, Yngve that limit infection, these cytokines are recognized for their pleiotropic effects, to assess T1-IFN-mediated effects on auto-reactive CTL responses, and to universitet. Avhandling: Exploring the pleiotropic effects of technology on society or making social lemonade from technological lemons : six rules for marketers. Pleiotropic effects of GIP on islet function involve osteopontin.
Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
2017 — Lipids Health Dis. 15, 118 (2016). Davidson, M. H. Clinical Significance of Statin Pleiotropic Effects Hypotheses Versus Evidence. Circulation. renal effects of glucagon like peptide 1 analog and peptidyl Peptidase-4 inhibitor in rats.
2021-01-28 the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. 2014-04-08 Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Moeller BJ(1), Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW. Author information: (1)Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. 2020-06-06 PLEIOTROPIC EFFECTS OF STATINS Dr.RENJU.S.RAVI MD 2.